As always, we're covering FanDuel's main slate, which kicks off at 10 a.m. EST on Saturday. All betting lines come from the soccer odds at FanDuel Sportsbook and FoxBet, and they may change after the article is published.
Slate Overview
Tottenham (+110) at Leicester (+240)
Over 2.5 Goals: -134 | Most Likely to Score: Kane (+110)
Brighton (+100) at Crystal Palace (+280)
Over 2.5 Goals: +100 | Most Likely to Score: Ferguson (+190)
Nottingham Forest (+320) at Fulham (-115)
Over 2.5 Goals: +102 | Most Likely to Score: Mitrovic (+100)
Brentford (+650) at Arsenal (-230)
Over 2.5 Goals: -142 | Most Likely to Score: Nketiah (+135)
Wolves (+155) at Southampton (+195)
Over 2.5 Goals: +132 | Most Likely to Score: Onuachu (+135)
Newcastle (-185) at Bournemouth (+550)
Over 2.5 Goals: +100 | Most Likely to Score: Wilson (+145)
Positional Breakdown
Forwards/Midfielders
Arsenal are the epicenter of this six-game slate. The league-leading Gunners are -230 to win at home against Brentford and are -200 to go over 1.5 goals -- both of which are slate-best marks. Brentford are no pushover, but the betting market is strongly backing Arsenal to get back on track after last week's defeat at Everton. Arsenal have been lights out at home this year, scoring 25 goals in nine home matches.
The Gunners' big four -- Eddie Nketiah ($18; +135 anytime goal odds), Bukayo Saka ($20; +175), Martin Odegaard ($19; +245) and Gabriel Martinelli ($18; +185) -- are all top-notch options. Odegaard's goal odds are just meh, but he's a much more enticing -135 to score or assist. He's my favorite play from this foursome, although you can make a strong case for any of the four.
The other side I definitely want a piece of is Newcastle, who are -185 to win at Bournemouth. The Cherries have been a team we've picked on all season, and there's no reason to stop now. On paper, this is a big mismatch. Bournemouth have conceded a league-high 43 times through 21 matches while the Magpies' attack has amassed the fourth-most expected goals, per FBRef. Newcastle are -149 to score at least twice.
Callum Wilson ($21; +135) has the best goal odds on Newcastle, and Alexander Isak ($19; +175) is plenty viable if he starts. Joelinton ($16; +280), Anthony Gordon ($15; +220) and Allan Saint-Maximin ($26; +280) are worthwhile targets who come at a salary discount from Wilson. ASM is -120 to score/assist, which is tied (with Wilson) for the best odds on the team.
Tottenham are worth a mention as a talented side that could go overlooked. Spurs are just +110 to win at Leicester and are -105 to go over 1.5 goals. The Foxes have conceded the fourth-most xG, so even though Spurs' attack hasn't been flying, I think they're worth getting exposure to. This match is -134 to see at least three goals, which is the second-best number on the slate.
Harry Kane ($23; +110) isn't going to fly under the radar, but Son Hueng-Min ($17; +200) and Dejan Kulusevski ($15; +290) might. Son and Kulusevski are -105 and +100, respectively, to score/assist.
Playing at home versus Nottingham Forest, Fulham are worth a look, too, and Aleksandar Mitrovic ($23; +100) is one of the slate's best plays. His +100 goal odds pace the slate, and he's -170 to score/assist. Fulham are +100 to go over 1.5 goals. Willian ($14; +250) and Andreas Pereira ($15; +320) are lower-salaried pivots off the likely chalky Mitrovic or can be used alongside him if you're bullish on Fulham.
Added time -- Evan Ferguson ($16; +190) and Kaoru Mitoma ($18; +195) are savvy plays for a Brighton side that could slip through the cracks despite a friendly matchup at Palace. ... James Maddison ($18; +300) is +150 to score/assist and benefits from what should be a fantasy-friendly environment against Tottenham, who are without their first-choice keeper. ... The Wolves-Southampton match is an ugly +132 to go over 2.5 goals. I'll mostly stay away outside of sprinkling in some Paul Onuachu ($14; +135) and Matheus Cunha ($14; +240), the two with the match's top goal odds. Onuachu is one of the best value plays on the board.
Defenders
I hyped up Kieran Trippier ($16) last week, and he produced a blah 14.2 FanDuel points, his worst fantasy outing since October 1st. The fact that 14.2 FanDuel points was underwhelming for him says a lot, because that's still a pretty good output. The salary is tough to get to, but Trippier -- who is +195 to score/assist -- is in a smash spot at Bournemouth. He's my favorite way to get a piece of Newcastle and is a priority for me on Saturday.
Tottenham's Ivan Perisic ($10) is +150 to score/assist, a slate-best mark for the position, and his salary is easy to love. The matchup with Leicester should suit him well, and he's due for a spike week as he continues to get into dangerous positions.
Arsenal's Oleksandr Zinchecko ($9) hasn't been a fantasy force this year but is a low-salary way to get a player who spends some time in attacking areas and plays for the slate's biggest favorite.
On the Bees' side of the Brentford-Arsenal match, Ethan Pinnock ($15) and Ben Mee ($12) offer high floors. They should soak up a lot of pressure at the Emirates. Pinnock is averaging 20.0 FanDuel points per match and has scored 33.4, 24.5 and 22.1 FanDuel points in his past three games against big-six sides. Mee generated 10.4, 13.4 and 20.4 FanDuel points in those matches.
Added time -- Despite scoring only 3.9 FanDuel points last weekend, Tariq Lamptey ($7) was a constant threat and could've easily had a much bigger day. He's a sweet value play in a date with Palace. ... Fulham's Kenny Tete ($13) has scored at least 15.1 FanDuel points in eight straight matches and is a great stacking partner for Mitrovic.
Goalies
If it's the win and clean-sheet bonuses you're after, make room for Aaron Ramsdale ($13) or Nick Pope ($13).
Pope is +105 to keep a clean sheet and -185 to win. Newcastle have been elite defensively and should keep Bournmouth's attack pretty quiet. The Cherries have scored just once in their past six EPL matches. I prefer Pope between these two.
Ramsdale is +100 to blank Brentford and -230 to get the win. Arsenal haven't been as rock-solid defensively of late, allowing at least 1.0 xG in five of their last six league matches. Brentford's attack has been red-hot, too, scoring at least two goals in seven of their last eight fixtures. You can, however, flip that to a positive for Ramsdale as it should require him to make a few saves, giving him a huge ceiling if he can keep a clean sheet.
Fulham's Bernd Leno ($12) checks some boxes. The matchup is a good one as he's home to Forest, a side that is tied for the third-fewest goals (17) this campaign.
Wolves-Southampton is a decent spot to go clean-sheet hunting as both attacks rank in the bottom three in goals for the season. I give Gavin Bazunu ($10) a slight edge over Jose Sa ($11).
Added time -- Brighton's Robert Sanchez ($12) is a fun GPP pivot. Salaried up near Pope and Ramsdale, Sanchez should go overlooked, and he's a solid +160 to keep a clean sheet at Palace. ... Vicente Guiata ($9) isn't a bad pick on the Palace side. Brighton usually generate plenty of chances, which gives Guiata the potential for good save volume. ... David Raya ($7) can be a decent dart throw. I think Brentford put up a good fight at Arsenal, and the save volume will be there. His salary frees up coin for the rest of your lineup.